Alfentanil
Pharmacology Alfentanil is a synthetic derivative of fentanyl. It has a more rapid onset of action, shorter duration of action…
Analgesic use in renal failure
Traditionally serum creatinine has been used as a measure of renal function. This is inaccurate as patients may have a…
Complex Regional Pain Syndrome
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Ketamine
Not recommended for use without specialist supervision Ketamine is an NMDA receptor antagonist (NMDA receptor activation reduces opioid sensitivity) Acts…
Lidocaine
Introduction Lidocaine is an amide local anaesthetic that is a non-selective sodium channel blocker Acts by suppressing ectopic neural discharges…
Local CCG Pain Guidelines
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Methadone
Not recommended for use without specialist supervision Methadone has both opioid and non-opioid properties and a much longer half life…
Octreotide
Octreotide (Sandostatin) is the longer acting synthetic analogue of the naturally occurring hormone somatostatin. In the hypothalamus it inhibits the…
Palliative Care Guidelines website
http://book.pallcare.info/ The website above hosts the Palliative Care Guidelines developed by a collaboration of UK Cancer networks and the Welsh…
Phenobarbitone
NOT RECOMMENDED FOR USE WITHOUT SPECIALIST PALLIATIVE CARE SUPERVISION Indication for use Terminal restlessness / delirium not responding…
Pruritus
Pruritus is an unpleasant sensation which provokes the desire to scratch. Causes / risk factors Allergies Renal –…
Spinal cord compression
Spinal cord compression occurs in 3-5% of patients with advanced cancer. Cancers of the breast, bronchus and prostate account for…
Superior vena cava obstruction
Superior vena cava obstruction (SVCO) is generally caused by extrinsic compression by metastases in upper mediastinal lymph nodes. It may…